Medchemexpress LLC T025 | 2407433-00-3 | 99.6% | 382.42 | 100 MG

Supplier:  Medchemexpress LLC HY112296100MG

T025 is an orally active and highly potent inhibitor of Cdc2-like kinase (CLKs), demonstrating Kd values of 4.8, 0.096, 6.5, 0.61, 0.074, 1.5, and 32 nM for CLK1, CLK2, CLK3, CLK4, DYRK1A, DYRK1B, and DYRK2, respectively. This compound induces caspase-3/7-mediated cell apoptosis and reduces CLK-dependent phosphorylation. T025 exhibits anti-proliferative activities in both hematological and solid cancer cell lines with IC50 values ranging from 30-300 nM, making it primarily useful for MYC-driven disease research.

• Orally active and highly potent inhibitor of Cdc2-like kinase (CLKs)
• Induces caspase-3/7-mediated cell apoptosis
• Reduces CLK-dependent phosphorylation
• Exerts anti-proliferative activities in both hematological and solid cancer cell lines
• Anti-tumor efficiency, mainly for MYC-driven disease research

Catalog No. 50-004-36741