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Medchemexpress LLC T0467 | 859518-94-8 | 99.3% | 441.49 | 50 MG
SDP

Supplier:  Medchemexpress LLC HY13930850MG

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T0467 activates parkin mitochondrial translocation in a PINK1-dependent manner in vitro. It does not induce mitochondrial accumulation of PINK1 in dopaminergic neurons. It is a potential compound for PINK1-Parkin signaling activation and can be used for Parkinson's disease and related disorders research.

  • Activates parkin mitochondrial translocation in a PINK1-dependent manner in vitro.
  • Does not induce mitochondrial accumulation of PINK1 in dopaminergic neurons.
  • Potential compound for PINK1-Parkin signaling activation.
  • Can be used for Parkinson's disease and related disorders research.
  • Stimulates mitochondrial translocation of GFP-Parkin in HeLa/GFP-Parkin cells.
  • Mitigated PINK1 inactivation-mediated larval locomotion defects and mitochondrial morphological defects in Drosophila.
  • Reduced ATP production in Drosophila.
  • Improved mitochondrial Ca2+ response in Drosophila larval muscles.

Catalog No. 50-003-49509


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