Apexbio Technology LLC TAI-1 1334921-03-7 25mg

Supplier:  Apexbio Technology LLC B489225

TAI-1 (CAS 1334921-03-7) is a small molecule inhibitor targeting the protein Hec1 It functions by disrupting the interaction between Hec1 and Nek2 prompting Nek2 degradation chromosome misalignment at metaphase and apoptotic cell death Demonstrating a GI50 of 13 48 nM in K562 cells TAI-1 exhibits significantly increased inhibitory potency compared to earlier Hec1 inhibitors such as INH1 TAI-1 displays antiproliferative activity across diverse tumor cell types particularly in cell lines lacking functional P53 or RB genes It also enhances chemotherapeutic efficacy when combined with agents like topotecan paclitaxel and doxorubicin TAI-1 is orally active in in vivo models supporting its utility as a practical tool in oncology research

Catalog No. 50-000-62882