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Apexbio Technology LLC Tandutinib (MLN518) HCl 387867-13-2 (free base) 200mg
Supplier: Apexbio Technology LLC B7853200
Tandutinib MLN518 HCl is a small-molecule inhibitor targeting receptor tyrosine kinases including FLT3 PDGFR and c-Kit It is designed to inhibit these kinases by competitively interfering with their ATP-binding sites thereby suppressing downstream signaling pathways such as Akt/mTOR MAP kinase and PI3 kinase Tandutinib MLN518 HCl exerts its biological activity primarily through kinase inhibition In FLT3-ITD-positive acute myeloid leukemia (AML) cell models and colon cancer research models Tandutinib MLN518 HCl demonstrates inhibition of cell proliferation receptor autophosphorylation tumor cell growth colony formation and angiogenesis-related gene expression Based on these pharmacological properties Tandutinib MLN518 HCl holds research potential in investigating signaling mechanisms and therapeutic avenues in leukemia and solid tumors
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