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Apexbio Technology LLC Tariquidar(Synonyms: XR9576, Tariquidar fumarate, XR-9576, UNII-1W8830WSA2, P-glycoprotein inhibitor XR9576), 10mM (in 1mL DMSO), CAS: 206873-63-4.
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Supplier:  Apexbio Technology LLC A82085.1

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Tariquidar (CAS 206873-63-4) is a small-molecule inhibitor targeting the efflux transporter P-glycoprotein (Pgp) Pgp a 170-kDa transmembrane protein functions primarily as an ATP-dependent drug efflux pump removing structurally diverse molecules from cells Tariquidar acts through noncompetitive inhibition of Pgp-associated basal ATPase activity thereby reducing drug efflux In vitro assays across several cell models demonstrate tariquidar-mediated Pgp inhibition with IC50 values ranging from 15 to 223 nM Due to its selectivity for Pgp tariquidar serves as a significant research tool in studies of drug resistance and transporter-mediated drug disposition

Catalog No. 50-000-60471


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