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Cayman Chemical TatCBD3trIfluoroACTAte sa 10mg
Supplier: Cayman Chemical 3744810 MG
An inhibitor of the Cav2.2-CRMP2 protein-protein interaction; inhibits the protein-protein interaction between CRMP2 and the NMDA receptor NR2B subunit; inhibits the Cav2.2-CRMP2 interaction by 43% in a cell-free assay and the NMDA receptor NR2B subunit-CRMP2 interaction in an immunoprecipitation assay at 10 µM; reduces voltage-induced calcium currents by approximately 60% in primary rat DRG neurons and glutamate-induced increases in cytosolic calcium levels in primary rat hippocampal neurons; decreases infarct volume in a rat model of MCAO-induced cerebral ischemia at 20 mg/kg; intrathecal administration prevents carrageenan-induced thermal hypersensitivity in rats
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