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Medchemexpress LLC Tazemetostat | 1403254-99-8 | 572.74 | 1 G
SDP

Supplier:  Medchemexpress LLC HY138031G

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Tazemetostat (EPZ-6438) is a potent, selective, and orally available EZH2 inhibitor. It inhibits the activity of human polycomb repressive complex 2 (PRC2)-containing wild-type EZH2 with a Ki value of 2.5 nM. It also inhibits EZH2 with IC50s of 11 nM in peptide assay and 16 nM in nucleosome assay. Tazemetostat induces apoptosis and differentiation specifically in SMARCB1-deleted MRT cells.

  • Potent, selective, and orally available EZH2 inhibitor.
  • Inhibits wild-type EZH2 with a Ki of 2.5 nM.
  • Inhibits rat EZH2 with an IC50 of 4 nM.
  • Induces apoptosis and differentiation in SMARCB1-deleted MRT cells.

Catalog No. 50-003-50013


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