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Medchemexpress LLC Tazemetostat | 1403254-99-8 | 572.74 | 25 MG
Supplier: Medchemexpress LLC 25MGHY13803R
Tazemetostat (EPZ-6438) is a potent, selective, and orally available EZH2 inhibitor. It inhibits human polycomb repressive complex 2 (PRC2)-containing wild-type EZH2 with a Ki value of 2.5 nM. It inhibits EZH2 with IC50s of 11 and 16 nM in peptide and nucleosome assays, respectively, and rat EZH2 with an IC50 of 4 nM. Tazemetostat also inhibits EZH1 with an IC50 of 392 nM. It induces apoptosis and differentiation specifically in SMARCB1-deleted MRT cells.
- Potent, selective, and orally available EZH2 inhibitor.
- Induces apoptosis and differentiation specifically in SMARCB1-deleted MRT cells.
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