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Medchemexpress LLC TC-Mps1-12 | 1206170-62-8 | 99.8% | 324.38 | 100 MG
Supplier: Medchemexpress LLC HY1101151MG
TC-Mps1-12 is a potent and selective monopolar spindle 1 (Mps1) inhibitor, with an IC50 of 6.4 nM. It inhibits the growth of pMps1 cell lines and A549 cells in a dose-dependent manner, exhibiting good pharmacokinetic properties.
- Potent and selective Mps1 inhibitor
- Inhibits the growth of pMps1 cell lines with IC50 values of 131 nM in autophosphorylation assay
- Inhibits the growth of A549 cells in a dose-dependent manner in vivo, showing 47% tumor growth inhibition at 100 mg/kg without body weight loss
- Exhibits good PK properties with a Cmax of 3542 ng/mL and AUC of 6604 ng h/mL at an oral dose of 25 mg/kg
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