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Medchemexpress LLC TCO-NHS ester | 1191901-33-3 | 97.0% | C13H17NO5 | 25 MG
Supplier: Medchemexpress LLC 25MGHY141165
TCO-NHS ester is an alkyl/ether-based PROTAC linker designed for use in the synthesis of PROTACs. This compound functions as a click chemistry reagent, featuring a TCO group. This TCO group is capable of undergoing an inverse electron demand Diels-Alder reaction (iEDDA) when combined with molecules that contain Tetrazine groups. PROTACs themselves are composed of two distinct ligands connected by a linker: one ligand targets an E3 ubiquitin ligase, and the other targets a specific protein. Their mechanism of action involves leveraging the intracellular ubiquitin-proteasome system to achieve selective degradation of target proteins.
- Alkyl/ether-based PROTAC linker for PROTAC synthesis.
- Functions as a click chemistry reagent.
- Contains a TCO group that reacts with Tetrazine groups via iEDDA.
- Enables the creation of PROTACs which selectively degrade target proteins via the ubiquitin-proteasome system.
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