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Medchemexpress LLC Tco-peg12-nhs ester | 2185016-39-9 | 96.3% | 866.99 g/mol | C40H70N2O18 | 5 MG
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Supplier:  Medchemexpress LLC HY1411705MG

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TCO-PEG12-NHS ester is a polyethylene glycol (PEG12) linker containing a trans-cyclooctene (TCO) moiety and an N-hydroxysuccinimide (NHS) ester reactive group. It is used for bioconjugation in research applications, including the synthesis of antibody-drug conjugates (ADCs) and PROTACs, where it provides a cleavable, water-soluble spacer that facilitates targeted payload delivery.

  • Provides a PEG12 spacer to increase water solubility and reduce steric hindrance.
  • Contains an NHS ester for efficient coupling to primary amines.
  • Features a TCO group for rapid, bioorthogonal click chemistry reactions.
  • Suitable as a cleavable linker in ADC synthesis and as a linker in PROTAC design.
  • Supplied in small research quantities for laboratory synthesis and conjugation workflows.

Catalog No. 50-002-02222


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