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Medchemexpress LLC TCV-309 chloride | 121494-09-5 | 95.0% | 629.97 | 1 ML
Supplier: Medchemexpress LLC HY19121A10MM/1ML
TCV-309 chloride is a potent and specific platelet activating factor (PAF) antagonist. It specifically inhibits PAF-induced aggregation of rabbit and human platelets, and [3H]PAF binding to rabbit platelet microsomes with IC50 values of 33 nM, 58 nM and 27 nM, respectively. TCV-309 chloride has beneficial effects in anaphylactic shock. For research use only.
- Potent and specific platelet activating factor (PAF) antagonist.
- Inhibits PAF-induced aggregation of rabbit and human platelets.
- Inhibits [3H]PAF binding to rabbit platelet microsomes.
- Beneficial effects in anaphylactic shock.
- Selectively inhibits PAF-induced hypotension, hemoconcentration, and death in rats.
- Most potently protects mice from death induced by PAF and due to anaphylactic shock.
- Reversed PAF-induced hypotension and endotoxin-induced hypotension in rats.
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