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Medchemexpress LLC Tenofovir alafenamide hemifumarate | 1392275-56-7 | C21H29N6O5P.1/2 C4H4O4 | 50 MG
Supplier: Medchemexpress LLC HY15232B50MG
Tenofovir alafenamide hemifumarate is an investigational oral prodrug of Tenofovir, an HIV-1 nucleotide reverse transcriptase inhibitor. It offers good oral bioavailability and increased plasma stability compared to Tenofovir disoproxil fumarate (TDF).
- Antiviral activities range from 5 to 7 nM across all cell types
- CC50 varies from 4.7 to 42 μM for MT-4 and MT-2 cells, respectively
- Effective against a panel of HIV-1 and HIV-2 isolates
- Mean EC50 for 29 primary HIV-1 isolates in PBMCs is 3.5 nM
- Mean EC50 for HIV-2 isolates is 1.8 nM
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