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Medchemexpress LLC Tenofovir Disoproxil fumarate | 202138-50-9 | 99.5% | 635.51 | 50 MG
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Supplier:  Medchemexpress LLC HY1378250MG

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Tenofovir Disoproxil fumarate is a nucleotide reverse transcriptase inhibitor used to treat HIV and chronic Hepatitis B. It is for research use only.

  • Used to treat HIV and chronic Hepatitis B
  • Functions as a nucleotide reverse transcriptase inhibitor
  • Shows cytotoxic effects on HK-2 cells with IC50 values of 9.21 and 2.77 μM at 48 and 72 hours
  • Diminishes ATP levels and increases oxidative stress in HK-2 cells
  • Induces apoptosis in HK-2 cells via mitochondrial damage
  • Inhibits replication of R5-tropic HIV-1BaL and X4-tropic HIV-1IIIb in activated PBMCs
  • Significantly reduces HIV transmission in BLT mice
  • Induces dose-dependent decline in serum viremia in woodchucks chronically infected with WHV
  • Demonstrated as safe and effective in the woodchuck model of chronic HBV infection

Catalog No. 50-003-51206


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