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Medchemexpress LLC Tenofovir exalidex | 911208-73-6 | 99.8% | 569.72 | 100 MG
SDP

Supplier:  Medchemexpress LLC HY10901450MG

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Tenofovir exalidex (CMX157) is a lipid conjugate of the acyclic nucleotide analog Tenofovir. It is active against both wild-type and antiretroviral drug-resistant HIV strains, including multidrug nucleoside/nucleotide analog-resistant viruses. It is effective against all major subtypes of HIV-1 and HIV-2 in fresh human PBMCs and against all HIV-1 strains evaluated in monocyte-derived macrophages, with EC50s ranging between 0.2 and 7.2 nM. CMX157 is orally available, has no apparent toxicity, and also shows antiviral activity against HBV.

  • Consistently >300-fold more active than Tenofovir against multiple viruses
  • Effective against MNR mutants unresponsive to currently available NRTIs
  • Inhibits HBV polymerase-mediated HBV DNA elongation

Catalog No. 50-003-45154


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