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Apexbio Technology LLC Tenovin-3 1011301-27-1 1mg
Supplier: Apexbio Technology LLC A85671
Tenovin-3 (CAS 1011301-27-1) is a small molecule inhibitor of sirtuin deacetylases specifically targeting SirT2 and is structurally characterized by a tert-butyl group (R ) and an amino group (R ) In cellular models Tenovin-3 was shown to increase p53 protein levels in MCF-7 cells and elevate K40 acetylated tubulin in H1299 cells at a treatment concentration of 10 M Its ability to inhibit SirT2 activity and modulate downstream acetylation events has made Tenovin-3 a useful probe for studying sirtuin biology p53 regulation and the cellular effects of deacetylase inhibition in cancer and cell signaling research
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