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Apexbio Technology LLC TGX-221 663619-89-4 5mg
Supplier: Apexbio Technology LLC A26815
TGX-221 (CAS 663619-89-4) is a potent and selective inhibitor of phosphoinositide 3-kinase (PI3K) p110 isoform exhibiting an IC50 of 8 5 nM In cellular studies TGX-221 reduces insulin-stimulated phosphorylation of protein kinase B (PKB/Akt) at Ser473 in J774 2 macrophages without affecting PKB phosphorylation in CHO-IR or 3T3-L1 cells In vivo TGX-221 administration in murine models of arterial thrombosis increases blood flow and prolongs bleeding times and reduces mortality rates in rat thrombus models TGX-221 is utilized in research exploring PI3K function in cellular signaling and thrombotic disease mechanisms
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