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Apexbio Technology LLC TH588 1609960-31-7 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC B58455.1
TH588 (CAS 1609960-31-7) is a selective small-molecule inhibitor of MTH1 (MutT Homolog 1) a purine nucleoside triphosphatase that prevents incorporation of oxidized nucleotides into DNA TH588 inhibits MTH1 with an IC50 of 5 nM and has been shown to increase DNA 8-oxodG levels in cancer cells leading to DNA damage and activation of ATM-p53-mediated cell death and repair pathways In cellular models such as U2OS and other cancer cell lines TH588 preferentially induces cytotoxicity in malignant cells with reduced effects on primary or immortalized non-cancerous cells In BRAF V600E mutant melanoma xenografts TH588 treatment attenuates tumor growth supporting its use in research on oxidative stress DNA damage and novel anticancer strategies
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