Medchemexpress LLC Thalidomide 4-fluoride | 835616-60-9 | 99.9% | 276.22 | 5 G

Supplier:  Medchemexpress LLC HY415475G

Thalidomide 4-fluoride is a Thalidomide-based Cereblon ligand that recruits CRBN protein and can be linked to the ligand for IRAK4 protein to create PROTAC IRAK4 degrader-1. This compound targets cereblon (CRBN), a ubiquitous protein involved in the cullin-4 E3 ubiquitin ligase complex CRL4, facilitating the ubiquitination and subsequent proteasomal degradation of target proteins.

• Recruits CRBN protein.
• Can be linked to IRAK4 protein ligand.
• Targets cereblon (CRBN).
• Facilitates ubiquitination and proteasomal degradation of target proteins.
• Molecular weight: 276.22.
• Physical state: solid.
• Color: off-white to gray.
• Soluble in DMSO.
• Store powder at -20°C for 3 years or 4°C for 2 years.
• Store in solvent at -80°C for 2 years or -20°C for 1 year.
• Avoid repeated freeze-thaw cycles after preparation into solution.

Catalog No. 50-004-04911