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Medchemexpress LLC Thalidomide-5-PEG2-Cl | 2230956-57-5 | 96.57% | 380.78 | 100 MG
Supplier: Medchemexpress LLC HY139543100MG
Thalidomide-5-PEG2-Cl is a Thalidomide-based cereblon ligand involved in the recruitment of CRBN protein. It can be connected to a protein's ligand via a linker to form PROTACs. PROTACs utilize two different ligands connected by a linker: one binds to an E3 ubiquitin ligase, and the other targets the desired protein, leveraging the intracellular ubiquitin-proteasome system for selective degradation of target proteins.
- Utilized in the recruitment of CRBN protein
- Can be linked to a protein's ligand to form PROTACs
- Exploits the intracellular ubiquitin-proteasome system
- Enables selective degradation of target proteins
- Functions as an E3 ligase ligand-linker conjugate
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