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Bachem Astressin Trifluoroacetate

Supplier:  Bachem 4026664.1000

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Astressin Trifluoroacetate, H-D-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Nle-Ala-Arg-Ala-Glu-Gln-Leu-Ala-Gln-cyclo(-Glu-Ala-His-Lys)-Asn-Arg-Lys-Leu-Nle-Glu-Ile-Ile-NH2, 170809-51-5, C161H269N49O42, Mr 3563.24, 1mg. (D-Phe12,Nle21·38,cyclo(Glu30-Lys33))-CRF (12-41) (human, rat). The Glu30 to Lys33 lactam bridge constrains astressin in an a-helical conformation which seems to be responsible for its especially high CRF antagonist activity. Astressin is 100 times more potent than a-helical CRF (9-41) at inhibiting ACTH secretion in vitro, and more than 10 times more potent in vivo than any other CRF antagonist reported to date.

Catalog No. 50-194-6987


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