Bachem Astressin, 1mg, 170809-51-5, MFCD00798715, Trifluoroacetate salt
Manufacturer: Bachem 4026664.1000
The Glu³⁰ to Lys³³ lactam bridge constrains astressin in an α-helical conformation which seems to be responsible for its especially high CRF antagonist activity. Astressin is 100 times more potent than α-helical CRF (9-41) at inhibiting ACTH secretion in vitro, and more than 10 times more potent in vivo than any other CRF antagonist reported to date.
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