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Lonza Walkersville The PyroCell Monocyte Activation Test – FBS Rapid System contains cryopreserved, pooled PBMC (human, pMAT Cells), MAT Culture Medium Supplement, PeliKine human IL-6 ELISA Rapid Kit, for 288 tests .
Supplier: Lonza Walkersville 296407
The Monocyte Activation Test (MAT) is an in vitro assay for pyrogen testing in pharmaceutical and medical device industries. The Monocyte Activation Test principle is based on the detection of pro-inflammatory cytokines released by human monocytes in response to exogenous endotoxins (LPS) and non-endotoxin pyrogens (NEP). The Monocyte Activation Test has been adopted by the European Pharmacopeia in 2010 (Ph. Eur. chapter 2.6.30) Today, the Monocyte Activation Test is MAT recognized as a compendial method for pyrogen testing in several world regions including Europe. Here, the Monocyte Activation Test will be fully replacing the Rabbit Pyrogen Test (RPT) as of 2026. The Monocyte Activation Test is further compliant to the EU Directive 2010/63/EU on the protection of experimental animals.
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