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Apexbio Technology LLC Thiamet G 1009816-48-1 25mg
Supplier: Apexbio Technology LLC B204825
Thiamet G (CAS 1009816-48-1) is a selective small molecule inhibitor targeting human O-GlcNAcase an enzyme responsible for removing O-linked N-acetylglucosamine (O-GlcNAc) modifications from serine and threonine residues on proteins Thiamet G demonstrates potent inhibitory activity with a Ki of 21 nM and effectively elevates cellular O-GlcNAcylation levels in NGF-differentiated PC-12 cells (EC50 30 nM) In vitro and in vivo experiments indicate that Thiamet G reduces phosphorylation of tau proteins at multiple sites associated with neurodegeneration Additionally it enhances sensitivity of human leukemia cells to the chemotherapeutic paclitaxel suggesting its utility in neurological and oncological research
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