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STEMCELL Technologies Thiazovivin, Size: 5 mg
Supplier: STEMCELL Technologies 72254
Thiazovivin is a selective inhibitor of Rho-associated coiled-coil containing protein kinase (ROCK), a serine/threonine kinase that plays a role in cell polarity, contraction, and actin cytoskeleton reorganization (Xu et al.). Thiazovivin is effective at 5-fold-lower concentrations than another common ROCK inhibitor Y-27632 (Catalog #72302; Xu et al.).MAINTENANCE AND SELF-RENEWAL· Promotes survival of human embryonic stem (ES) cells during dissociation by stabilizing E-cadherin and improves cell attachment (Xu et al.).· Promotes survival of single human induced pluripotent stem (iPS) cells during transfection for TALEN-mediated genome editing (Sun and Zhao).REPROGRAMMING· Increases the efficiency of reprogramming human somatic cells to iPS cells, in combination with PD0325091 and SB431542 (Lin et al.).· Increases the efficiency of reprogramming human cord blood mononuclear cells to iPS cells (Hu et al.).
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