Cayman Chemical ThIordoxIn Rducts 1 InhIb 25mg

Supplier:  Cayman Chemical 3130725 MG

An irreversible inhibitor of TrxR1 (IC50 = 0.012 µM); inhibits TrxR1-induced reduction of Trx1 in a cell-free assay (IC50 = 4.3 µM); reduces the mitochondrial oxygen consumption rate in HCT116 cells at 10 µM; increases the intracellular levels of hydrogen peroxide in FaDu cancer cells in a time- and concentration-dependent manner; decreases the viability of FaDu cells (IC50 = 0.72 µM); decreases tumor growth in a FaDu HNSCC mouse xenograft model at 10 mg/kg twice per day; induces apoptosis in a FaDu HNSCC mouse xenograft model at 5 mg/kg daily; toxic to S. mansoni adult worms (LD50 = 10.07 µM)

Catalog No. 50-299-1898