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Apexbio Technology LLC Thiorphan 76721-89-6 10mg
Supplier: Apexbio Technology LLC C434910
Thiorphan (CAS 76721-89-6) is a potent inhibitor of neprilysin a zinc-dependent metalloprotease involved in the degradation of various peptide hormones and amyloid beta peptides Neprilysin inhibition by thiorphan (Ki 4 140 nM) modulates peptide metabolism and has implications in neurodegenerative research due to the enzyme s role in amyloid beta clearance In vitro thiorphan demonstrates dose-dependent antiproliferative activity on A549 lung carcinoma cells In vivo it has shown neuroprotective properties in models of cortical injury Thiorphan is also relevant for studying enkephalinase inhibition and peptide-mediated signaling in both preclinical and translational research contexts
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