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Apexbio Technology LLC Tivantinib (ARQ 197) 905854-02-6 100mg
Supplier: Apexbio Technology LLC A8325100
Tivantinib (ARQ 197 CAS 905854-02-6) is a selective orally bioavailable small molecule inhibitor of the receptor tyrosine kinase c-MET (hepatocyte growth factor receptor) working through a non-ATP-competitive binding mechanism Tivantinib inhibits recombinant human c-MET with a Ki value of approximately 355 nmol/L It also demonstrates modest inhibitory activity against VEGFR-3 Pim-1 calmodulin-dependent kinase II delta and p21-activated kinase 3 In vitro studies reveal cytotoxicity against various human tumor cell lines (EC50 60-600 nmol/L) independent of c-MET gene amplification or MET protein expression Mechanistically it induces mitotic arrest and apoptosis Tivantinib is used experimentally in tumor biology research showing anti-tumor activities across multiple cancer xenograft models
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