Medchemexpress LLC Tivantinib (ARQ 197) | 905854-02-6 | 99.6% | 369.42 | 5 MG

Supplier:  Medchemexpress LLC 5MGHY50686

Tivantinib is a highly selective c-Met tyrosine kinase inhibitor with a Ki of 355 nM. It is a low-molecular-weight compound and the first orally available selective inhibitor of c-Met. Tivantinib selectively inhibits c-Met activity in cell-free and cell-based assays, causing dose-dependent loss of proliferative capacity or caspase-dependent apoptosis in c-Met-expressing cancer cell lines.

• Highly selective c-Met tyrosine kinase inhibitor
• Ki of 355 nM
• Selectively inhibits c-Met activity in cell-free and cell-based assays
• First orally available selective inhibitor of c-Met
• Inhibits constitutive c-Met phosphorylation in HT29 and MKN-45 cells, and HGF-induced c-Met phosphorylation in MDA-MB-231 and NCI-H441 cells with an IC50 of 100 to 300 nM
• Strongly inhibits c-Met phosphorylation in human colon xenograft tumors (HT29)

Catalog No. 50-003-93420