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Medchemexpress LLC Tk-129 | 3031476-73-7 | C15H23N5O2 | 1 ML
Supplier: Medchemexpress LLC HY15148310MM/1ML
TK-129 is an orally active, low-toxicity, and potent KDM5B inhibitor with a high affinity (IC50=44 nM). It demonstrates cardioprotective effects by inhibiting KDM5B and interfering with the KDM5B-associated Wnt pathway. In vitro studies, TK-129 reduces ang II-induced activation of cardiac fibroblasts. In vivo, it has been shown to reduce isoprenaline-induced myocardial remodelling and fibrosis. This compound is suitable for use in studies related to cardiovascular disease.
- Orally active
- Low-toxicity
- Potent KDM5B inhibitor
- High affinity (IC50=44 nM)
- Cardioprotective effects
- Inhibits KDM5B and blocks the KDM5B-associated Wnt pathway
- Reduces ang ii-induced activation of cardiac fibroblasts in vitro
- Reduces isoprenaline-induced myocardial remodelling and fibrosis in vivo
- Suitable for cardiovascular disease studies
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