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Medchemexpress LLC TL02-59 | 1315330-17-6 | 99.9% | 609.64 | 50 MG
Supplier: Medchemexpress LLC 50MGHY112852
TL02-59 is an orally active, selective Src-family kinase Fgr inhibitor with an IC50 of 0.03 nM. It also inhibits Lyn and Hck with IC50s of 0.1 nM and 160 nM, respectively. This compound potently suppresses acute myelogenous leukemia (AML) cell growth.
- Selective Src-family kinase Fgr inhibitor with high potency.
- Inhibits Lyn and Hck.
- Potently suppresses acute myelogenous leukemia (AML) cell growth.
- Induces growth arrest and apoptosis in AML cell lines.
- Eliminates AML cells from spleen and peripheral blood in mouse models.
- Significantly suppresses bone marrow involvement in mouse models.
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