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Cayman Chemical TLR7 AgonIst 2 5mg
Supplier: Cayman Chemical 284505 MG
A TLR7 agonist (LEC = 0.4 μM in a cell-based reporter assay); selective for TLR7 over TLR8 (LEC = >100 μM); increases IFN-α levels and the ISG response, increasing the expression of Oas1b, Isg15, and Mx1, in mouse liver and plasma at 0.3-10 mg/kg; increases plasma levels of IFN-α, CCL2, IL-6, IL-1Ra, G-CSF, and IL-10 in cynomolgus monkeys at 10 mg/kg; reduces serum and liver viral load in the HDI-HBV mouse model at 0.3-5 mg/kg
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