Medchemexpress LLC Tnf-α-in-6 | 2699704-20-4 | 99.6% | C26H25N9O2 | 10MG

Supplier:  Medchemexpress LLC HY14261810MG

TNF-α-IN-6 is a small-molecule, orally active allosteric inhibitor of tumor necrosis factor alpha (TNF-α) reported to bind TNF with high affinity (KD = 6.8 nM) and to exhibit anti-inflammatory effects in animal models. Manufacturer datasheet lists formula C26H25N9O2 and molecular weight 495.54 g·mol⁻¹; in vivo oral dosing (0, 10, 30, 100 mg/kg, twice daily, 17 days) reduced paw swelling in mice.

• Allosteric inhibitor of TNF-α.
• High affinity binding (KD = 6.8 nM).
• Demonstrated anti-inflammatory activity in vivo.
• Active orally with defined dosing regimens in animal studies.
• Soluble ≥2.5 mg/mL in 10% DMSO/40% PEG300/5% Tween-80/45% saline vehicle.
• Chemically defined: formula C26H25N9O2; MW 495.54 g·mol⁻¹.

Catalog No. 50-002-58162