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Medchemexpress LLC Toddalolactone | 483-90-9 | 308.33 | 20 MG
Supplier: Medchemexpress LLC HYN051820MG
Toddalolactone is a natural coumarin that serves as a main component of *Toddalia asiatica*. It functions as an inhibitor of recombinant human plasminogen activator inhibitor-1 (PAI-1), demonstrating an IC50 value of 37.31 μM. Its inhibitory action on PAI-1 is attributed to its ability to prevent the formation of a stable PAI-1/uPA covalent complex, suggesting interference with the close contact between plasminogen activator and the active site of PAI-1.
- Main component of *Toddalia asiatica*.
- Inhibits recombinant human plasminogen activator inhibitor-1 (PAI-1) activity.
- Has an IC50 value of 37.31 μM against PAI-1.
- Prevents the formation of a stable PAI-1/uPA covalent complex.
- Suggested mechanism of action involves interference with the interaction between plasminogen activator and the active center of PAI-1.
- High purity: 99.97%.
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