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Apexbio Technology LLC Tofacitinib (CP-690550) Citrate(Synonyms: Xeljanz, CP-690550 citrate, Tofacitinib citrate, Tasocitinib citrate, CP690550-10 citrate), 10mg, CAS: 540737-29-9.
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Supplier:  Apexbio Technology LLC A413510

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Tofacitinib citrate (CP-690550 citrate CAS 540737-29-9) is an inhibitor of Janus kinase 3 (JAK3) a hematopoietic cell-restricted tyrosine kinase that regulates lymphocyte proliferation differentiation survival and apoptosis via intracellular signaling pathways It selectively inhibits JAK3 with an IC50 of approximately 1 nM exhibiting weaker inhibitory activity towards JAK2 and JAK1 (approximately 20-fold and 100-fold weaker respectively) Recent binding affinity studies indicate Ki values of 1 6 nM 21 7 nM and 6 5 nM for JAK1 JAK2 and JAK3 respectively Tofacitinib is widely explored in biomedical research involving immune regulation and inflammatory disorders

Catalog No. 50-000-60940


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