Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
Learn More
Medchemexpress LLC Tolcapone | 134308-13-7 | 99.9% | 273.24 | 5 MG
Supplier: Medchemexpress LLC HY174065MG
Tolcapone (Ro 40-7592) is a selective, potent, and orally active COMT inhibitor with an IC50 of 773 nM. It inhibits α-syn and Aβ42 oligomerization and fibrillogenesis, and can induce oxidative stress, causing apoptosis and ROS production in cancer cells. It is used for research related to cancer and neurological diseases, such as Parkinson's disease and neuroblastoma.
- Inhibits α-synuclein fibrillization.
- Inhibits α-syn seed-induced polymerization.
- Inhibits Aβ42 fibrillization.
- Inhibits Aβ42 seed-induced polymerization.
- Protects PC12 cells against α-syn and Aβ42-induced toxicity.
- Induces apoptosis in neuroblastoma cells.
- Increases reactive oxygen species levels in cells.
- Decreases the ATP per cell ratio in neuroblastoma cells.
- Inhibits tumor growth and prolongs survival in xenograft mouse models.
Product Title
By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.
Spot an opportunity for improvement?