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Cayman Chemical TolebrutInIb 10mg
SDP

Supplier:  Cayman Chemical 3772310 MG

Encompass_Preferred

A dual inhibitor of COX and 5-LO (IC50s 2.84 and 0.15 UM respectively in RBL-1 cell lysates) inhibits the activity of 12- but not 15- LO (IC50s 4.45 and 146.6 UM for the human platelet and rabbit reticulocyte enzymes respectively) reduces A23187-induced TXB2 and LTB4 production in human PBMCs (IC50s 0.01 and 0.07 UM respectively) and decreases epinephrine-induced platelet aggregation in human PRP (IC50 0.045 UM) inhibits paw swelling in a rat model of adjuvant-induced arthritis (ED50 3.5 mg/kg)

Catalog No. 50-291-6275


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