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Medchemexpress LLC Tos-PEG4-t-butyl ester | 217817-01-1 | 100 MG
SDP

Supplier:  Medchemexpress LLC HY130422100MG

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Tos-PEG4-t-butyl ester is a PROTAC linker characterized by its PEG composition. It is utilized in the synthesis of various PROTACs, including BI-3663. BI-3663 is a highly selective PTK2/FAK PROTAC that employs cereblon ligands to facilitate E3 ligase hijacking for PTK2 degradation, demonstrating an IC50 of 18 nM for PTK2 inhibition.

  • PROTAC linker
  • Used in the synthesis of PROTACs
  • Specific application in creating highly selective PTK2/FAK PROTACs
  • Inhibits PTK2 with an IC50 of 18 nM when used in PROTACs

Catalog No. 50-003-38776


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