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TARGETMOL CHEMICALS INC TOSEDOSTAT 5MG
SDP

Supplier:  TARGETMOL CHEMICALS INC T63015MG

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Also available in 1 mg 2 mg 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Tosedostat (CHR-2797) is an orally bioavailable inhibitor of the M1 family of aminopeptidases with potential antineoplastic activity. Tosedostat is converted intracellularly into a poorly membrane-permeable active metabolite (CHR-79888) which inhibits the M1 family of aminopeptidases particularly puromycin-sensitive aminopeptidase (PuSA) and leukotriene A4 (LTA4) hydrolase; inhibition of these aminopeptidases in tumor cells may result in amino acid deprivation inhibition of protein synthesis due to a decrease in the intracellular free amino acid pool an increase in the level of the proapoptotic protein Noxa and cell death. purity: 99%

Catalog No. 50-257-6537


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