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List Biological Laboratories Inc Toxin A from Clostridium difficile, 100 μg
SDP

Supplier:  List Biological Laboratories Inc 152C

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Since 1978, List Labs products are unsurpassed in quality, consistency, and reliability for the success of your research and development projects! Clostridium difficile is the causative agent of antibiotic-associated diarrhea and pseudomembranous colitis. It produces two major exotoxins (Toxin A and Toxin B), which are the prototypes of the family of large clostridial cytotoxins. Clostridium difficile A and B are high molecular weight glucosyltransferases that inhibit members of the Rho family of GTPases. Toxin A, referred to as an enterotoxin, has a molecular weight of 300 kDa and a pl of 5.3. Toxin B, known as a cytotoxin, has a molecular weight of 270 kDa and a pl of 4.1. By inhibition of signal transduction cascades, Toxin A and Toxin B are able to block downstream responses. Only Toxin A has been shown to have a binding site on epithelial cell surface carbohydrates which may be linked to a dramatic reaction seen in rabbit ileum.

Catalog No. NC9870978


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