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Apexbio Technology LLC TP-0903 1341200-45-0 5mg
Supplier: Apexbio Technology LLC B59405
TP-0903 (CAS 1341200-45-0) is a small molecule inhibitor targeting the AXL receptor tyrosine kinase with an in vitro IC50 of 0 027 M for AXL AXL along with other TAM family members contributes to the maintenance of mesenchymal phenotypes in cancer cells facilitating increased migration invasion and resistance to targeted therapies TP-0903 has demonstrated potent cytotoxic effects in cell-based assays such as reduced viability of PSN-1 pancreatic cancer cells and the inhibition of GAS6-mediated AXL activation In preclinical models TP-0903 reverses mesenchymal-driven drug resistance restoring sensitivity to agents like Erlotinib
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