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Selleck Chemical LLC TP0427736 HCl
Supplier: Selleck Chemical LLC S870010MM/1ML
TP0427736 is a potent inhibitor of ALK5 kinase activity with an IC50 of 2 72 nM and this effect is 300-fold higher than the inhibitory effect on ALK3 (IC50 836 nM for ALK3) It also inhibits Smad2/3 phosphorylation in A549 cells induced by TGF- 1 with an IC50 value of 8 68 nM
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