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Selleck Chemical LLC TP0427736 HCl 5mg 864374-00-5
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Supplier:  Selleck Chemical LLC S87005MG

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TP0427736 is a potent inhibitor of ALK5 kinase activity with an IC50 of 2.72 nM and this effect is 300-fold higher than the inhibitory effect on ALK3 (IC50 = 836 nM for ALK3). It also inhibits Smad2/3 phosphorylation in A549 cells induced by TGF-?1 with an IC50 value of 8.68 nM. *For Research & Development use only.  Product is not intended for drug, household, or human consumption.

Catalog No. 50-194-8352


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