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Medchemexpress LLC Trazodone | 19794-93-5 | 99.8% | 50 MG
Supplier: Medchemexpress LLC HYB0478A50MG
Trazodone (AF-1161 free base) is a triazolopyridine derivative and a serotonin receptor antagonist and reuptake inhibitor (SARI). It demonstrates anti-depressant and anti-insomnious activity. It also shows antagonistic properties against a1- and a2-adrenergic receptors and histamine H1 receptors, with minimal anticholinergic effects.
- Binds to 5-HT1A receptor with a Ki of 23.6 nM.
- Reduces neuroinflammatory markers by inhibiting NF-κB, p38 MAPK, and JNK pathways.
- Exhibits neuroprotective effects.
- Increases mRNA expression of BDNF and CREB.
- Decreases IFN-γ release.
- Decreases spontaneous firing rate of DR 5-HT neurons and blocks 5-HT reuptake.
- Reduces spontaneous motor activity, hyperactivity, prostration, and clonic convulsions in animal models.
- Inhibits nicotine and oxotremorine-induced tremor.
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