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Apexbio Technology LLC Triciribine 35943-35-2 50mg
Supplier: Apexbio Technology LLC A854150
Triciribine also known as API-2 is a selective inhibitor of Akt kinase activity targeting Akt1 Akt2 and Akt3 without affecting upstream regulators PDK1 and PI3K It suppresses Akt phosphorylation at Thr308 and Ser473 sites triggering apoptosis and growth inhibition in multiple cancer cell models with an IC50 of approximately 130 nM Additionally Triciribine exhibits antiviral activity against HIV-1 inhibiting viral replication and syncytia formation at an IC50 of 20 nM In biomedical research Triciribine is employed to investigate Akt-associated signaling pathways and evaluate potential therapeutic strategies targeting Akt-dependent tumors and HIV infections
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