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Medchemexpress LLC Trimethylamine N-oxide dihydrate | 62637-93-8 | >98.0% | 111.14 | 10 MG
Supplier: Medchemexpress LLC HY108915100G
Trimethylamine N-oxide dihydrate is a gut microbe-dependent metabolite of dietary choline and other trimethylamine-containing nutrients. It induces inflammation by activating the ROS/NLRP3 inflammasome. Additionally, it accelerates fibroblast-myofibroblast differentiation and induces cardiac fibrosis by activating the TGF-β/smad2 signaling pathway.
- Gut microbe-dependent metabolite of dietary choline and other trimethylamine-containing nutrients.
- Induces inflammation by activating the ROS/NLRP3 inflammasome.
- Accelerates fibroblast-myofibroblast differentiation and induces cardiac fibrosis by activating the TGF-β/smad2 signaling pathway.
- Can be used in animal modeling to create cardiovascular and metabolic disease models.
- Found in tissues of various marine organisms, protecting against adverse effects of temperature, salinity, high urea, and hydrostatic pressure.
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