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Medchemexpress LLC Trispiro[3H-indole-3,2'-dioxane-5',5''-dioxane-2'',3'''-[3H]indole]-2,2'''-dione | 442644-28-2 | MFCD03036757 | 98.15% | 394.38 | 10 MG
SDP

Supplier:  Medchemexpress LLC HY108442100MG

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JW67 inhibits canonical Wnt signaling with an IC50 of 1.17 μM. It affects the multiprotein complex of β-catenin/GSK-3β/AXIN/APC/CK1, leading to a rapid reduction in active β-catenin and downregulation of Wnt target genes. This compound also inhibits colorectal cancer cell growth and reduces cell viability in SW480 cells.

  • Inhibits canonical Wnt signaling with an IC50 of 1.17 μM
  • Reduces active β-catenin and downregulates Wnt target genes
  • Inhibits colorectal cancer cell growth
  • Increases AXIN2 concentration and decreases active β-catenin in vitro
  • Reduces colon cancer cell growth in vitro
  • Shows concentration-dependent reduction in proliferation with a GI50 value of 7.8 μM

Catalog No. 50-003-47003


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