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Cayman Chemical TrnscrIptIonFactrp53PrIm1ea
Supplier: Cayman Chemical 6000231 EA
An inhibitor of the protein-protein interaction between Rac1 and TIAM1 inhibits the interaction between Rac1 and TIAM1 in a cell-free assay at 200 UM active against chloroquine-resistant and -susceptible strains of P. falciparum (IC50 17.56 and 12.56 respectively) inhibits the proliferation of MDA-MB-231 F3II and MCF-7 cells (IC50s 48 61 and 31 UM respectively) induces cell cycle arrest at the G1 phase in MDA-MB-231 cells at 10 UM inhibits EGF-induced actin polymerization in and the migration and invasion of MDA-MB-231 and F3II cells at 50 UM reduces the number of lung nodules in an F3II murine model of lung metastasis at 25 mg/kg per day
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