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Cayman Chemical TropIsetronhydrochlorIde 50mg
Supplier: Cayman Chemical 2124050 MG
A 5-HT3 receptor antagonist (Ki = 0.8 nM for the mouse receptor); selective for 5-HT3 over 5-HT4 (Ki = 156 nM for the porcine receptor); an antagonist of the α9 nAChR (IC50 = 166 nM for the rat receptor); a partial agonist of α7 nAChR (Ki = 6.9 nM for the rat receptor); enhances glycine-induced potentiation of homomeric α1 but not homomeric α2 glycine receptors at 10 µM; blocks 5-HT-induced depolarizations in isolated rabbit nodose ganglia at 0.1 nM; exhibits anti-emetic effects in a ferret model of cisplatin-induced emesis at 1 mg/kg
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