Medchemexpress LLC TRPM7-IN-1 | 1909225-07-5 | 98.8% | 419.48 | 5 MG

Supplier:  Medchemexpress LLC HY1686085MG

TRPM7-IN-1 (compound SUD), a benzoylurea derivative, is an effective TRPM7 inhibitor. It induces cell cycle arrest and apoptosis, and decreases the migration of MCF-7 and BGC-823 cells. It also decreases vimentin expression and increases E-cadherin expression. This compound potentially reduces TRPM7-like current and decreases TRPM7 expression through the PI3K/Akt signaling pathway, making it a potential agent to suppress the metastasis of breast and gastric cancer by inhibiting TRPM7 expression and function.

• Effective TRPM7 inhibitor.
• Induces cell cycle arrest and apoptosis.
• Decreases migration of MCF-7 and BGC-823 cells.
• Decreases vimentin expression and increases E-cadherin expression.
• Potentially reduces TRPM7-like current and decreases TRPM7 expression via the PI3K/Akt signaling pathway.
• Potential agent to suppress metastasis of breast and gastric cancer.

Catalog No. 50-003-90421