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Medchemexpress LLC TSPO ligand-1 | 4560-08-1 | C16H10ClNO2 | 50 MG
Supplier: Medchemexpress LLC HY15040750MG
TSPO ligand-1 is a ligand of AUTAC4 and can be used in the synthesis of PROTACs. This mitochondrial outer membrane transmembrane structural domain protein binds to AUTAC4, regulating mitochondrial autophagy to promote targeted mitochondrial renewal. It is also involved in the transport of cholesterol from the outer to inner mitochondrial membrane and acts as a sensitive biomarker of brain injury and neurodegeneration.
- Regulates mitochondrial fatty acid oxidation (FAO), affecting mitochondrial energy homeostasis.
- Serves as a marker of glial cell activity in Alzheimer's disease.
- Shows increased expression with selective neuronal activation.
- Exhibits elevated levels under physiological and psychopharmacological neuronal activation.
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